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Neurophysiology, excitability, translational reseach


DURATION 18 months (multiple renewal possible)
BRIEF DESCRIPTION OF THE PROJECT Based on new data obtained in the lab, neurons in an iso-electric brain (i.e., without spontaneous activity as occurring during deep coma) keep a remarkable functional and intrinsic excitability. The project aims at describing this excitability and redefine neural state giving rise to specific comas. The primary task will be to take over the duties of the graduate student at the origin of the project, including record neuronal functional responses in anesthetized (intracellular, ECoG) and behaving (LFP) rats as well as in human patients (EEG).

One main objective of this translational study is to link the results in human patients and rat models, therefore excellent relational skills are essential to collaborate with neuroscientists in the lab and neurologists at the hospital.

Specific training will be provided, but electrophysiological expertise is required. Candidates should be highly motivated, meticulous, have good skills in quantitative analysis and be ready to participate in the overall scientific life of the lab. Experience in performing experiments in vivo is a plus.


Qualification & experience required PhD in neuroscience, MD with experience in single cell electrophysiology, or physicist with similar background.
Profile, skills & ability required Single cell and field electrophysiological recordings, experience with rodent handling and in vivo experiments, good relational skills, high motivation.


Contact: Stéphane Charpier


Intracerebral recordings, microelectrodes, epilepsy, spike sorting


DURATION 2 years (possible renewal)
STARTING DATE 01/11/2017

Single unit and LFP analysis in human epileptic patients

The general goal of this project is to improve knowledge on pathophysiology of epilepsy, in particular the interictal events and the epileptic seizures. With the development of intracerebral recordings with microelectrodes in our epileptic patients, we are now able since several years to perform continuous intracerebral recordings at different scales, from usual macroelectrodes to single neuron recordings, in the interictal period but also during seizures, in multiple intracerebral areas.

The main role of the position will be to perform electrophysiological analysis of intracerebral signals at different periods: during the interictal period and preictal period and to study the link with multiunit/single unit activities in cortical areas.

Main activities The doc /post-doc will be integrated in a multidisciplinary team including researchers, engineers, clinical electrophysiologists, neuroradiologists and neurosurgeons. He/she will receive a full assistance from an engineer for the data acquisition and storage. In addition, he/she will have inputs from several researchers/methodologists in signal analysis.
Qualification & experience required The candidate should have a PhD or equivalent in Signal analysis or Neuroscience related field. Expertise in signal processing and good analytical skills (MATLAB) are required, notably in spike sorting analysis. Since the analytic approaches needed for this study have been extensively developed and used in animals, previous experience in animal in vivo or in vitro experiments is a plus.
Application Process Candidates should submit curriculum vitae, a cover letter and contact information for two referees. Application should be sent to Pr Vincent Navarro

Contact: Vincent Navarro

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